Dicarboxylic acids and derivatives
Apexbio Technology LLC PKUMDL-LC-101-D04 2143896-83-5 25mg
PKUMDL-LC-101-D04 (CAS 2143896-83-5) is a small molecule allosteric activator of glutathione peroxidase 4 (GPX4) a key enzyme regulating ferroptosis In biochemical and cell extract assays PKUMDL-LC-101-D04 enhances GPX4 activity to 150% of baseline at concentrations of 20 M and 61 M respectively This compound serves as a valuable tool for investigating the modulation of ferroptosis through GPX4 activation and supports research into oxidative stress and cell death mechanisms
Medchemexpress LLC 7-((4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide | 1012054-59-9 | MFCD15528940 | >98.0% | 434.49 g/mol | C24H26N4O4 | 50 MG
CUDC-101 is a small-molecule research inhibitor of histone deacetylases (HDACs), epidermal growth factor receptor (EGFR), and HER2, used in preclinical cancer research to assess antiproliferative and target-specific effects.
- Potent inhibitor of HDAC, EGFR, and HER2 with low-nanomolar activity.
- Demonstrates broad antiproliferative effects across cancer cell lines.
- Supplied as a light yellow to yellow powder for laboratory use.
- High purity suitable for research applications (reported ≥98% by HPLC).
- Available in small-mass packaging for research workflows.
- Molecular weight 434.49 g/mol.
Medchemexpress LLC Sulforhodamine 101 DHPE | 187099-99-6 | >95.0% | 1381.84 | C74H117N4O14PS2 | 1MG
Sulforhodamine 101 DHPE is a red fluorescent phospholipid probe created by conjugating dipalmitoyl phosphoethanolamine to sulforhodamine 101. It readily incorporates into lipid bilayers and is used for membrane imaging, monitoring probe colocalization in liposomes, and detecting protein-ligand interactions on supported bilayers. The dye exhibits excitation/emission peaks near 586/605 nm and is supplied as a powder with recommended cold storage.
![Medchemexpress LLC Benzyl 3-[6-[[2-(butylamino)-1-[3-methoxycarbonyl-4-(2-methoxy-2-oxoethoxy)phenyl] | 831217-40-4 | 98.2% | 931.12 g/mol | C54H66N4O10 | 1MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238871.png-250.jpg)
Medchemexpress LLC Benzyl 3-[6-[[2-(butylamino)-1-[3-methoxycarbonyl-4-(2-methoxy-2-oxoethoxy)phenyl] | 831217-40-4 | 98.2% | 931.12 g/mol | C54H66N4O10 | 1MG
MAL3-101 is a small-molecule allosteric inhibitor of heat shock protein 70 (HSP70) used in cellular and biochemical research. It inhibits HSP70 ATPase activity by blocking interaction with Hsp40 co-chaperones, perturbing protein folding and proteostasis pathways. The compound is supplied as a high-purity research reagent (CAS 831217-40-4) and is intended for in vitro and preclinical studies only.
- Allosteric inhibitor of HSP70 ATPase activity.
- Blocks Hsp40-Hsp70 interaction to disrupt protein folding.
- Applicable to cellular models studying proteostasis and cancer biology.
- High reported purity supports reproducible results.
- Supplied in small quantities suitable for screening and pilot studies.
- For research use only; not for human or veterinary use.
Selleck Chemical LLC MZ-101-E1913-25MG
MZ-101 (GYS1-IN-2) is a potent small molecule inhibitor of Glycogen synthase 1(GYS1) with an IC50 value of 0 041 M By depleting muscle glycogen MZ-101 treatment normalizes glycogen levels and corrects transcriptional and metabolic abnormalities in Pompe mice
Medchemexpress LLC Ethyl Lauroyl Argina 5g
Ethyl Lauroyl Arginate Hydrochloride is an arginine derivative[1]
Medchemexpress LLC BNC-101 1mg | 1mg
BNC-101 is a human-derived antibody expressed in CHO cells that targets GPR49/LGR5 The predicted molecular weight (MW) of BNC-101 is 150 kDa The isotype control for BNC-101 can refer to Human IgG1 kappa Isotype Control (HY-P99001)
Medchemexpress LLC 1,2-dilauroyl-3-chloropropanediol | 1051389-99-1 | MFCD34647394 | >98.0% | 475.14 g·mol⁻¹ | C27H51ClO4 | 5 MG
1,2-dilauroyl-3-chloropropanediol is a chloropropanediol ester used as a research-grade lipid reagent for analytical and synthetic applications. It has molecular formula C27H51ClO4, molecular weight ≈475.14 g·mol⁻¹, and CAS 1051389-99-1. The compound is typically supplied as a solid with reported purity >98% and is recommended to be stored at -20 °C.
- High purity (>98%) suitable for analytical and synthetic workflows.
- Well-defined molecular identity: C27H51ClO4; MW 475.14 g·mol⁻¹; CAS 1051389-99-1.
- Solid form facilitates accurate weighing and handling.
- Small pack sizes available for method development and reference use.
- Recommended cold storage to maintain stability.
Apexbio Technology LLC AT-101 90141-22-3 50mg
AT-101 (CAS 90141-22-3) is a natural BH3-mimetic isolated from cottonseed identified as a pan-inhibitor of the anti-apoptotic proteins Bcl-2 Bcl-xL and Mcl-1 Mechanistically AT-101 binds to the hydrophobic BH3-binding grooves of these Bcl-2 family proteins impeding their heterodimerization with pro-apoptotic members (e g Bad Bid and Bim) thereby restoring apoptotic signaling pathways It has been shown to promote apoptosis in cell-based assays via caspase-9 activation and modulation of Puma Noxa Bax and XIAP protein expression Preclinical studies demonstrate anti-tumor activity in prostate cancer xenografts AT-101 is currently evaluated in clinical trials against castration-resistant prostate cancer and other cancers
Medchemexpress LLC PKUMDL-LC-101-D04 500mg | 2143896-83-5 | 378.93 g·mol⁻¹ | C14H23ClN4O2S2 | 500 MG
PKUMDL-LC-101-D04 is a small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) used in research on ferroptosis, lipid peroxidation, and inflammation. It increases GPX4 enzymatic activity in cell-free and cellular assays (reported pEC50 = 4.7) and protects cells from cholesterol peroxide-induced toxicity.
- Allosteric activator of GPX4, reported pEC50 = 4.7.
- Increases GPX4 activity to ~150% in cell-free and cellular extracts at reported concentrations.
- Demonstrated inhibition of ferroptosis and protection against lipid peroxide-induced cell death.
- Molecular weight ~378.93 g·mol⁻¹ and chemical formula C14H23ClN4O2S2.
- Supplied as a high-purity research chemical suitable for biochemical and cellular assays.
AdipoGen Sulforhodamine 101 acid Cl
Chemical. CAS 82354-19-6. Formula C31H29ClN2O6S2. MW 625.15. Synthetic. Sulforhodamine 101 sulfonyl chloride also called Texas Red sulfonyl chloride is a popular long wavelength amine-reactive rhodamine dye. Because the dye is quite unstable in water, reactions with amines in an aqueous solution must be carried out at low temperature over ice or at 4°C and usually at pH 8.5.
AdipoGen Sulforhodamine 101 acid Cl
Chemical. CAS 82354-19-6. Formula C31H29ClN2O6S2. MW 625.15. Synthetic. Sulforhodamine 101 sulfonyl chloride also called Texas Red sulfonyl chloride is a popular long wavelength amine-reactive rhodamine dye. Because the dye is quite unstable in water, reactions with amines in an aqueous solution must be carried out at low temperature over ice or at 4°C and usually at pH 8.5.
Medchemexpress LLC MZ-101 (GYS1-IN-2) | 2839908-40-4 | 99.0% | 449.52 | C25H28FN5O2 | 10 MG
MZ-101 (GYS1-IN-2) is an orally active, potent, and selective small-molecule inhibitor of glycogen synthase 1 (GYS1) with an IC50 of 0.041 μM. It reduces glycogen concentrations in cells and in mice and is used to study GYS1-mediated Pompe disease and other glycogen storage disorders.
- Potent, selective GYS1 inhibition (IC50 = 0.041 μM).
- Reduces glycogen concentrations in cells and animal models.
- Orally active small molecule suitable for in vivo studies.
- High purity (98.98%) and solid physical form for storage stability.
- Available in small solid quantities and DMSO solutions for flexible dosing.
- Storage: powder stable at -20 °C (up to three years) and 4 °C (up to two years).